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Abstract The presence of ecgonine in urine has been proposed as an appropriate marker of cocaine use. Only a few methods have been published for their determination along with cocaine and the rest The recoveries were 81% and 75.3% for benzoylecgonine and ecgonine methyl ester, respectively. The intra-assay precision (% relative standard deviation) at two different added amounts (200 and 1000 ng/mL) in urine matrix varied from 4.8 to 8.4 and from 4.4 to 5.7, respectively. Ecgonine methyl ester 1.0 mg/mL in Acetonitrile | Certified Reference Material: A certified Snap-N-Spike® solution standard suitable for use in LC/MS or GC/MS testing applications including forensic analysis, urine drug testing, and clinical toxicology.

Benzoylecgonine (BZE) is the mayor metabolite of cocaine in urine and its presence (NorCE), ecgonine (EC) and anhydroecgonine methyl ester (AEME) were A study on the stability of anhydroecgonine methyl ester (crack biomarker), benzoylecgonine, and cocaine in human urine. Estudo da estabilidade do éster 1 Mar 2010 Urinary excretion of ecgonine (EC) was compared to that of cocaine, benzoylecgonine, ecgonine methyl ester and minor metabolites, quantitation of ecgonine methyl ester (EME), benzoylec- gonine (BE), cocaine ( COC) and cocaethylene (CE) in human urine was developed using the Thermo ABSTRACT. Analytical methods were evaluated for measuring cocaine (CO), ben - zoylecgonine (BE), and ecgonine methyl ester (EME) in urine and metha-. Urinary ecgonine methyl ester accounted for 26 to 60% of the cocaine dose. Ecgonine methyl ester had an elimination halflife of 4.2 hr, compared with 5.1 hr for Rapid confirmation/quantitation of ecgonine methyl ester, benzoylecgonine, and cocaine in urine using on-line extraction coupled with fast HPLC and tandem 1 Nov 1977 Benzoylecgonine and Ecgonine Methyl Ester Concentrations in Urine Specimens . Journal of Forensic Sciences 1995, 40 (1) , 13769J.

It is the corresponding carboxylic acid of cocaine, its methyl ester. ecgonine: [ ek´go-nin ] the final basic product obtained by hydrolysis of cocaine and several related alkaloids. La benzoylecgonine (benzoate d'ecgonine) est le principal métabolite de la cocaïne.Elle est formée dans le foie par le métabolisme de la cocaïne, catalysée par les carboxylestérases et excrétée par l'urine.

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The two major urinary metabolites of cocaine are benzoylecgonine (BE) and ecgonine methyl ester (EME). The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening. ecgonine methyl ester, then to ecgonine (Ambre et al. 1988).

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It has a role as a central nervous system depressant, a peripheral nervous system drug, an analgesic, a metabolite, an opioid analgesic and a mouse metabolite. It is a tropane alkaloid, a methyl ester and a tertiary amino compound. It derives from an ecgonine. Ecgonine methyl ester is a major urinary metabolite of cocaine, a popular illicit drug well known as "crack" or the free base form of cocaine that can be smoked. This stable-labeled internal standard is suitable for use in cocaine testing or isotope dilution methods for GC/MS or LC/MS applications in urine drug testing, clinical toxicology or forensic analysis. Benzoylecgonine can be detected in urine within four hours after cocaine intake and remains detectable in concentrations greater than 150 ng/mL typically for up to eight days after cocaine is used.

It is most frequently used as a recreational drug. It is commonly snorted, inhaled as smoke, or dissolved and injected into a vein. Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation.
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A sensitive and specific bioanalyt- "Confirmation and Quantitation of Cocaine, Bezoylecgonine, Ecgonine Methyl Ester in Human Urine by GC/MS." Journal of Analytical Technology Vol.12 (1988): 153-55. Thuyne, W.Van, and F.T. Delbeke. "Distribution of Caffeine Levels in Urine in Different Sports in Relation to Doping Control Before and After the Removal of Caffeine from the WADA Urine drug testing is an important part of managing long-term opioid therapy. With the recent increase in deaths caused by opioid overdoses, several federal and state regulations have been enacted Ambre JJ, Ruo TI, Smith GL, Backes D, Smith CM 1982 Ecgonine methyl ester, a major metabolite of cocaine. J Anal Toxicol 6 : 26–29.

CAS Article Google Scholar Recently, ecgonine methyl ester (methylecgonine) has been shown to be major urinary metabolite of cocaine in man after oral administration. These results indicate that ecgonine methyl ester is a prominent urinary metabolite after street use of cocaine, which primarily involves intranasal application and intravenous injection rather than ingestion. In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen conditions. This is a comment on "Sensitive, selective, and rapid procedure for the quantitation of ecgonine methyl ester in urine." J Anal Toxicol. 1991 Nov-Dec;15(6):345. This is a comment on "Sensitive, selective, and rapid procedure for the quantitation of ecgonine methyl ester in urine." J Anal Toxicol. 1991 Nov-Dec;15(6):345.
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The overall recoveries were 49% for methyl ecgonine, 35% for ethyl ecgonine, 29% for ecgonine and more than 83% for all other drugs. Abstract The presence of ecgonine in urine has been proposed as an appropriate marker of cocaine use. Only a few methods have been published for their determination along with cocaine and the rest The recoveries were 81% and 75.3% for benzoylecgonine and ecgonine methyl ester, respectively. The intra-assay precision (% relative standard deviation) at two different added amounts (200 and 1000 ng/mL) in urine matrix varied from 4.8 to 8.4 and from 4.4 to 5.7, respectively.
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Studying the causative factors, which alter the pharmacological and toxicological effects of COC, is of sig- nificant clinical importance. A sensitive and specific bioanalyt- Ambre JJ, Ruo TI, Smith GL, Backes D, Smith CM 1982 Ecgonine methyl ester, a major metabolite of cocaine. J Anal Toxicol 6 : 26–29. CAS Article Google Scholar Recently, ecgonine methyl ester (methylecgonine) has been shown to be major urinary metabolite of cocaine in man after oral administration. These results indicate that ecgonine methyl ester is a prominent urinary metabolite after street use of cocaine, which primarily involves intranasal application and intravenous injection rather than ingestion. In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen conditions. This is a comment on "Sensitive, selective, and rapid procedure for the quantitation of ecgonine methyl ester in urine." J Anal Toxicol.

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Abstract. The two major urinary metabolites of cocaine are benzoylecgonine (BE) and ecgonine methyl ester (EME). The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening. ecgonine methyl ester, then to ecgonine (Ambre et al. 1988).

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Excretion of benzoylecgonine in urine was 6.3-19.2% in dogs and 7.5-32.9% in rabbits. mination of benzoylecgonine and ecgonine methyl ester in human urine samples. After extraction and sample cleanup by solid-phase extraction (SPE), the extracts were derivatized with 50 μL of MTBSTFA and analyzed by gas chromatography/mass spectrometry (GC/MS). The limit of detection (LOD) was 50 ng/mL for both metabolites. 1984-01-01 The excretion kinetics of cocaine (C) and its two major metabolites, benzoylecgonine (BZ) and ecgonine methyl ester (EME), were determined by collecting all urine for Cocaine is rapidly hydrolyzed by blood cholinesterase to ecgonine methyl ester. Spontaneous chemical hydrolysis to benzoylecgonine also occurs and cocaine is therefore unstable in aqueous solution (and urine) at pH values above neutrality. A rapid, rugged, and highly specific assay for the quantitation of cocaine (COC) and especially its primary metabolites benzoylecgonine (BZE) and ecgonine methyl ester (EME) in human urine has 1988-01-01 This work describes a fast and fully validated procedure for the simultaneous detection and quantification of ecgonine, ecgonine‐methyl‐ester, benzoylecgonine, nor‐benzoylecgonine, m‐hydroxybenzoylecgonine, cocaethylene, cocaine, norcocaine and norcocaethylene in human urine (500 μL) using one SPE and simple derivatization.